Persons Who Should Not Be Vaccinated with LAIV

LAIV is not currently licensed for use in the following groups, and these persons should not be vaccinated with LAIV:

• persons with a history of hypersensitivity, including anaphylaxis, to any of the components of LAIV or to eggs.

• persons aged <5 years or those aged >50 years (note);

• persons with any of the underlying medical conditions that serve as an indication for routine influenza vaccination, including asthma, reactive airways disease, or other chronic disorders of the pulmonary or cardiovascular systems; other underlying medical conditions, including such metabolic diseases as diabetes, renal dysfunction, and hemoglobinopathies; or known or suspected immunodeficiency diseases or immunosuppressed states;

• children or adolescents receiving aspirin or other salicylates (because of the association of Reye syndrome with wild-type influenza virus infection);

• persons with a history of GBS; or

• pregnant women.

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